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Do not take Estrace with any of the following medications:

  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

Estrace may also interact with the following medications:

  • carbamazepine
  • certain antibiotics used to treat infections
  • certain barbiturates or benzodiazepines used for inducing sleep or treating seizures
  • grapefruit juice
  • medicines for fungus infections like itraconazole and ketoconazole
  • raloxifene or tamoxifen
  • rifabutin, rifampin, or rifapentine
  • ritonavir
  • St. John's Wort
  • warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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